Peptides for Appetite Suppression
Overview
3 research peptides are currently studied for appetite suppression. This guide ranks them by evidence strength and covers their mechanisms, safety profiles, and current clinical status.
Cholecystokinin (CCK) — Well-Characterized Physiology / Limited Therapeutic Application
Evidence Rating: B Category: Satiety / Gut-Brain Axis
Cholecystokinin (CCK) is a well-characterized endogenous gut-brain peptide hormone released by I-cells in the duodenum and jejunum in response to dietary fat and protein. It is one of the most extensively studied satiety hormones, with decades of research confirming its role in meal termination, gal...
Key claims: Induces meal-ending satiety; Stimulates gallbladder contraction and pancreatic secretion.
Peptide YY (PYY) — Human Infusion Studies / Well-Characterized Physiology
Evidence Rating: B Category: Satiety / Metabolic
Peptide YY (PYY) is a 36-amino-acid gut hormone released by L-cells in the ileum and colon following meals. PYY3-36, the predominant circulating form, acts on Y2 receptors in the hypothalamic arcuate nucleus to suppress appetite. It is one of the best-characterized satiety hormones, with human infus...
Key claims: Reduces caloric intake by ~30% in humans; Lower PYY levels in obesity.
Tesofensine — Phase II–III Clinical Trials
Evidence Rating: C Category: Weight Loss / Reuptake Inhibitor
Tesofensine is a triple monoamine reuptake inhibitor (serotonin, norepinephrine, dopamine) originally developed for Alzheimer's and Parkinson's disease. Phase 2 trials demonstrated approximately 10% body weight loss over 24 weeks, making it one of the most effective weight loss agents studied to dat...
Key claims: Produces significant weight loss (~10% body weight); Suppresses appetite and reduces caloric intake.
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