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Peptide Profiling Decodes TCR Specificity for Autoantigen Find
Researchers developed a system combining high-throughput yeast display and fine-tuned protein language models to create deep peptide recognition profiles for TCRs. This approach details binding against millions of peptides and outperforms models like AlphaFold3 in predicting T cell activation. The method identified novel autoantigens for ankylosing spondylitis and acute anterior uveitis using HLA-B*27:05-restricted TCRs.