All Comparisons
MOTS-c vs AOD-9604
Side-by-side comparison of evidence, mechanisms, dosing, safety, and regulatory status.
MOTS-c: DAOD-9604: C
| Attribute | MOTS-c | AOD-9604 |
|---|---|---|
| Category | Metabolic / Mitochondrial | Metabolic / Fat Loss |
| Evidence Rating | D — Preclinical | C — Phase I–II Clinical Trials |
| Clinical Status | Research-only / No human clinical trials completed (Phase 1 of analog CB4211 only) | Clinical development discontinued after Phase 2; GRAS status for food use |
| Mechanism | MOTS-c activates AMPK by inhibiting the folate cycle, causing accumulation of AICAR (an AMP analog). Activated AMPK shifts cells into energy-efficient mode: enhancing glucose uptake, fatty-acid oxidation, and mitochondrial respiration while downregulating fat storage and gluconeogenesis. Under stres... | AOD-9604 (C78H123N23O23S2) works through a dual-action mechanism: it accelerates breakdown of stored fat (lipolysis) via cAMP signaling and enzymatic activation (stimulating hormone-sensitive lipase), while simultaneously blocking formation of new fat (lipogenesis). It stimulates lipolysis in a mann... |
| Half-Life | Several hours; tissue effects may persist longer | ~30 minutes |
| Bioavailability | — | — |
| Molecular Weight | ~2174.6 g/mol | ~1815.1 g/mol |
| WADA Status | Not Listed | Prohibited |
| Dosing | 5–10 mg SC per injection, Once daily or 3–5x weekly (Subcutaneous) | 250–500 mcg/day SC, Once daily (Subcutaneous) |
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| Regulatory (US) | Not FDA-approved. Removed from FDA Category 2 on April 15, 2026. PCAC review scheduled July 23-24, 2026. Research chemical. | Not FDA-approved as a drug. FDA granted GRAS status for food use (2014). Available as research chemical. |
Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.
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